You Can Now ‘Snort’ Weed Using This Cannabis Nasal Spray
Update: This story has been updated to clarify certain statements and include comment from Vera Wellness.
When listing off drugs you can snort up your nose, marijuana usually doesn’t make the list. But with cannabinoid-spiked nasal sprays, that’s now possible, though when it comes to how high it gets you, sniffing might not be any different than smoking.
Homemade cannabis nasal sprays have existed on the fringes of the medical weed market for years now, but a Colorado company recently released a commercial version. Verra Wellness’s “nasal mist” comes in three ratios: 10:1 THC to CBD, 1:1, and 1:100. According to the company’s marketing material, spraying the mist up your nose allows for “increased bioavailability,” of the cannabinoids. But an expert I spoke to said there’s not much science to back up these kinds of claims.
“A lot of the stuff about bioavailability and any drug tends to be kind of hype-y,” said Dr. David Casarett, the chief of palliative care at Duke University who has researched and written about medical marijuana. “If one product had a bioavailability of 50 percent over, say, 25 percent, you could use a little less but it’s not like it’s a life changer.”
Casarett told me that ingesting cannabinoids through the nasal membrane does change the way it’s absorbed because it won’t first pass through your metabolism the way it does if you smoke or eat it. Verra Wellness’s co-founder Paul Johnson elaborated on how the nasal spray works differently than other methods, like smoking.
“Transmucosal delivery of cannabinoids by nasal spray is very different than smoking; It is safer and does not contain pyrolytic products (caused by heating) of a variety of compounds present in raw plant material,” Johnson wrote in an email. “We have developed formulations with good solubility properties, particle sizes, and sufficient purity to avoid subjecting delicate lung tissue to pharmacological action of cannabinoid formulations and typical impurities. We have worked with accredited labs to test our formulations for optimal delivery of cannabinoids.”
But it’s also harder to predict how your body will react to the drug when it enters your system by your nose.
“Absorption can be varied depending on what’s going on with your nose—if you have a cold or allergies, for example,” Casarett told me.
He also noted that the nasal membrane has high concentrations of enzymes that CBD has been found to deactivate, causing the body to temporarily not be able to metabolize other drugs, including THC. All of this means that it’s tricky to predict how a specific dose or ratio might affect you when you squirt it up your nostril instead of puffing it.
Casarett said this isn’t to say there’s anything wrong with nasal sprays—like any time you’re trying a new cannabis product, he recommends you “start low and go slow,” with your dosage. He also noted that it may be a more discreet way of consuming your cannabis since nasal sprays aren’t very obviously associated with weed the way, say, a bong is.
“I don’t see this being a game changer,” Casarett said. “But it is another option for people. “
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If that’s something you wanted to do.
What happens if you snort weed
A few years ago, award-winning actor and director Morgan Freeman touted the benefits of medical marijuana. “How do I take it?” he told The Daily Beast. “However it comes! I’ll eat it, drink it, smoke it, snort it!”
We all know we can eat, drink, and smoke weed. But can we snort it?
The short answer is yes. We can snort just about anything we can fit into our noses. One cannabis company already got the leg-up by offering a CBD nasal spray. Powdered weed, which is emulsified by binding cannabinoids to starches, can be snorted, too.
But can snorting weed actually get anyone high?
According to Brad Bogus, the VP of marketing at the data firm Confident Cannabis, yes, you can. If it’s got THC content.
Bogus recounted a story from 2017’s New West Summit, where one prominent industry leader was due to give a speech. While buzzed on booze, she snorted a couple lines of THC isolate, or pure THC crystals, which was handed out to attendees in the same little plastic bags one would find when scoring ketamine or coke.
Photo of the THC isolate at New West Summit 2017
“She was falling all over herself, completely incoherent and babbly. She lost her wallet and her phone,” Bogus told MERRY JANE. “Friends had to take her back to her hotel and request a ton of wake up calls for her so she would make her appearance.
“It was THC isolate, on top of alcohol,” Bogus continued, “but the sloppiness was totally a result of snorting two lines of isolate.”
The woman, whose identity was kept confidential, eventually recovered from snorting THC and went on to deliver a magnificent speech, he said.
How Is This Even Possible?
How could crystallized weed get someone high, though?
According to Jessie Gill, RN, the founder of Marijuana Mommy, a medical cannabis information website, cannabinoids like THC and CBD can be absorbed through the nasal lining, “just like they are absorbed when taken under the tongue.” Because the nasal passages are easily irritated, she strongly recommended never snorting anything, even weed.
But not all weed products are created equal. The bioavailability of a snorted cannabinoid depends on the product’s design. For example, snorting a line of pure kief won’t get anyone high, but it will burn the sinuses.
With isolates, the bioavailability through the nose remains low because cannabinoids don’t dissolve in water, Gill said. Mucous membranes lining the nasal passages are mostly made of water, which should repel substances like THC or CBD. It’s possible no one truly feels the effects of weed through their nose, but are instead feeling it after swallowing the sinus drip in the back of the throat.
However, Gill noted that because isolates are highly concentrated, “it’s easy to over-consume,” especially in CBD’s case. “Consuming high doses of CBD via any method can lead to overstimulation, which some people may interpret as a ‘buzz.’”
Above: Pure CBD isolate
CBD: THC’s Chillaxed Cousin
Wait a second, CBD can overstimulate the brain? CBD doesn’t get anyone high, though, right? That’s the mantra, anyway.
It started as a whisper at the fringes of medical science, amplified over the years by a swelling chorus of cannabis activists, patients, and advocates. Then the media began singing the same tune, and before we knew it, CBD popped up in drugstores and suburban kitchen cabinets, now infused into everything from hummus to underarm deodorant.
But some say snorting this supposed wonder drug — which offers the plant’s medicinal benefits and none of its side effects — can, indeed, get them a little buzzed.
But only a little.
Reddit is filled with personal accounts of people claiming they felt something after snorting CBD isolates. Unfortunately, Reddit users are anonymous, and many of them are thirsty for upvotes, making their claims questionable.
So, we talked to some people who weren’t hiding behind handles.
Rudy Sta Ana, the founder of Cannabis Catered Events, is a fusion weed chef based in California. He told MERRY JANE he’s snorted CBD twice in his life.
The first time happened after a dare. When he did it the second time, it was to prove to someone he’d done it before.
The effects, Sta Ana said, were immediate. “It felt like a euphoric boost and just made me feel great. It didn’t last very long, though.”
Jeremiah Baca, the owner of Phyto Therapeutic, an alternative healing center in Colorado, shared a similar account, although he mixed his CBD isolate with cacao powder.
“The effects were energizing and mood elevating,” Baca said. “And for someone with anxiety and depression, this is an application for quick relief. The effects were noticeable for about two to four hours.”
While Sta Ana insufflated CBD isolate for laughs, Baca did it as a wellness experiment, certain that the cannabinoid could absorb through the “thin walls of the nasal tissues” rich with tiny blood vessels.
Both men claimed they experienced no side effects.
Above: 99.9% Pure CBD Powder/Crystal
How CBD Could, Potentially, Get People Buzzed
Cannabinoids bind to cell proteins called cannabinoid, or CB, receptors. CB receptors act as locks on a cell, and cannabinoids essentially unlock them to trigger cell signaling. One of these receptors, CB1, mainly resides in the nervous system. Another receptor, CB2, can be found in the spleen and on immune cells.
THC, the part of weed that gets people stoned, binds tighter to CB1 receptors in the brain than it does to CB2 receptors in the immune system. This may be why THC couch-locks tokers and CBD doesn’t.
However, cannabinoid science is a young field. There are still a ton of kinks to work out.
Karl Young, the founder and lead chemist at Wesparklabs, believes CBD isn’t as sobering, or safe, as people think it is. He makes a product to treat cannabinoid hyperemesis syndrome, a vomiting illness he said is caused by a toxic build-up of CBD in the body.
“CBD spikes estrogen by suppressing” enzymes that break down estrogen and dopamine, he said. “If you suppress the ability to clear estrogen and dopamine, which is part of why people love CBD so much, you also suppress testosterone and serotonin from correct functionality.”
The result of snorting CBD isolate, according to Young, is a brief high that lightly resembles heroin or cocaine, two drugs that wreak havoc on the brain’s serotonin and dopamine networks. Prolonged CBD toxicity, he said, can lead to depression, liver failure, or suicidal thoughts, the same side effects seen with harder street drugs and opioids.
Young’s dopamine hypothesis is an outlier, as most scientists believe CBD can’t get anyone high.
“Cannabinoids have not been shown to appreciably affect hormone levels or dopamine signaling,” countered Marco Troiani, an organic chemist and CEO of Digamma Consulting. “You might feel ‘crazy’” after snorting CBD, “but that’s just because you put some junk up your nose that isn’t dissolving, and your nose’s mucous membrane isn’t happy.”
Troiani did offer one explanation for CBD causing a buzz, regardless of consumption method, though he wasn’t convinced of his own proposal.
CBD blocks an enzyme, fatty acid amide hydrolase or FAAH, which breaks down the body’s natural cannabinoids, anandamide and 2-AG. Studies show anandamide may share the same properties as THC, including the high.
“Both THC and CBD end up activating the CB1 receptor,” Troiani entertained. “THC does it directly, CBD does it through boosting our natural endocannabinoid, anandamide.” In other words, CBD could get someone buzzed in a roundabout way by causing a buildup of anandamide in the brain.
The Possibility of Pure Placebo
Dr. Adam Winstock, a psychiatrist and addiction specialist based in the UK, is also the founder of the Global Drug Survey. He said he’s never heard of anyone snorting cannabinoids, and he believes any claims of it causing a high, especially with CBD, are pure placebo.
In an email to MERRY JANE, Winstock wrote that some people may believe they’re catching a buzz from sniffing weed when all they’ve really done is suppressed some nagging symptoms such as anxiety, stress, or discomfort.
“A possible reduction in the discomfort of the thing you were trying to make better could be perceived as relief,” he wrote, “but I don’t think it could be perceived as a high.”
Winstock also suggested the “instrumental drug-seeking effect” could be at work. “People who are used to managing a stress by snorting a drug might get that expected effect” from snorting nasally inert weed products as well, he wrote.
Because so little research has been done on cannabis, or crystallized weed in particular, Winstock urged folks to remain skeptical, regardless of whether the alleged snorting-weed high is placebo or real.
“There’s lots of money out there, so I would be suspicious of every claim,” he cautioned. “The potential for profit can distort the truth and the stories people share.”
We all know we can eat, drink, and smoke weed. But can we snort it? We asked some experts to find out.