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An exploratory study of the combined effects of orally administered methylphenidate and delta-9-tetrahydrocannabinol (THC) on cardiovascular function, subjective effects, and performance in healthy adults

Affiliations

  • 1 Department of Psychiatry and Behavioral Science, Duke University School of Medicine, Durham, NC. Electronic address: [email protected]
  • 2 Department of Psychiatry; Seattle Children’s Hospital, Seattle, WA.
  • 3 Department of Psychiatry and Behavioral Science, Duke University School of Medicine, Durham, NC.
  • 4 Durham VA Medical Center, Durham, NC.
  • PMID: 25175495
  • PMCID: PMC4250392
  • DOI: 10.1016/j.jsat.2014.07.014

Free PMC article

An exploratory study of the combined effects of orally administered methylphenidate and delta-9-tetrahydrocannabinol (THC) on cardiovascular function, subjective effects, and performance in healthy adults

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Authors

Affiliations

  • 1 Department of Psychiatry and Behavioral Science, Duke University School of Medicine, Durham, NC. Electronic address: [email protected]
  • 2 Department of Psychiatry; Seattle Children’s Hospital, Seattle, WA.
  • 3 Department of Psychiatry and Behavioral Science, Duke University School of Medicine, Durham, NC.
  • 4 Durham VA Medical Center, Durham, NC.
  • PMID: 25175495
  • PMCID: PMC4250392
  • DOI: 10.1016/j.jsat.2014.07.014

Abstract

Methylphenidate (MPH) is commonly prescribed for the treatment of Attention Deficit Hyperactivity Disorder (ADHD), and is often used illicitly by young adults. Illicit users often coadminister MPH with marijuana. Little is known about physiologic and subjective effects of these substances used in combination. In this double-blind, cross-over experiment, sixteen healthy adult subjects free from psychiatric illness (including ADHD) and reporting modest levels of marijuana use participated in 6 experimental sessions wherein all combinations of placebo or 10mg oral doses of delta-9-tetrahydocannibinol (THC); and 0mg, 10mg and 40 mg of MPH were administered. Sessions were separated by at least 48 hours. Vital signs, subjective effects, and performance measure were collected. THC and MPH showed additive effects on heart rate and rate pressure product (e.g., peak heart rate for 10mg THC+0mg, 10mg, and 40 mg MPH=89.1, 95.9, 102.0 beats/min, respectively). Main effects of THC and MPH were also observed on a range of subjective measures of drug effects, and significant THC dose × MPH dose interactions were found on measures of “Feel Drug,” “Good Effects,” and “Take Drug Again.” THC increased commission errors on a continuous performance test (CPT) and MPH reduced reaction time variability on this measure. Effects of THC, MPH, and their combination were variable on a measure of working memory (n-back task), though in general, MPH decreased reaction times and THC mitigated these effects. These results suggest that the combination of low to moderate doses of MPH and THC produces unique effects on cardiovascular function, subjective effects and performance measures.

Keywords: Cannabis; Delta-9-tetrahydrocannabinol (THC); Methylphenidate; Prescription stimulant.

Copyright © 2014 Elsevier Inc. All rights reserved.

Methylphenidate (MPH) is commonly prescribed for the treatment of Attention Deficit Hyperactivity Disorder (ADHD), and is often used illicitly by young adults. Illicit users often coadminister MPH with marijuana. Little is known about physiologic and subjective effects of these substances used in co …

Ritalin weed

Saturday, 05 December

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It may indeed lead to the use of other drugs, but not necessarily so. Smoking weed is very common, especially among younger people. It isn’t good for the brain, and some people, unpredictably, may have really bad reactiosn to it including psychotic illness, and others just seem to become un-motivated, shallow and relatively inactive ‘ while others seem to smoke it for years without obvious. ill effects

Ritalin is a stimulant which is not good for someone taking it without prescription orreally good reason ; and someone taking it without medically identified need, may run into problems including possibly becoming dependent on it.

More relevant to him, perhaps, is the fact that like other stimulants ( like amphetamines) it doesn’t usefully improve study performance, but may improve his own satisfaction with his work, even if the work is substandard. As a student, I was impressed by the widely accepted story of a student, utterly happy on amphetamines he’d taken to stay awake and study, who went into the exam hall, wrote his name on the paper a couple of hundred times, and left, confident that he’s aced the examn.

Don’t get too concerned or too involved. No intervention is useful in drug use or abuse unless the individual himself is convinced that there are present or potential problems worth avoiding, and they sincerely want to use assistance to stop them.

And as he presumably spends most of the relevant part of the year at varsity, it might be most useful to encourage him to get involved through Student Health and Counselling services with a counsellor on campus, who can work with him there, to evaluate what intervention, if any, might be helpful

Ritalin weed Saturday, 05 December ADHD Expert Allergy expert Anti-ageing expert Asthma Expert Arthritis expert Breast cancer expert Cancer expert Cough