Smoking heroin with cannabis versus injecting heroin: unexpected impact on treatment outcomes
In several countries, especially in Africa, the dominant method of heroin intake is smoking a joint of cannabis laced with heroin. There is no data exploring the impact of smoking heroin with cannabis on treatment outcomes.
To compare treatment outcomes between people who inject heroin and people who smoke heroin with cannabis.
Three hundred heroin users were assessed on admission to inpatient rehabilitation and after treatment. We compared drug use, psychopathology, criminality, social functioning and general health between heroin injectors and heroin-cannabis smokers at treatment entry, and at 3 and 9 months after rehabilitation.
The sample comprised 211 (70.3%) heroin-cannabis smokers and 89 (29.7%) heroin injectors. Eighty-four percent were followed up at 3 months and 75% at 9 months. At 9 months, heroin-cannabis smokers had a higher proportion of those who relapsed to heroin use compared with intravenous (IV) users (p = 0.036). The median number of heroin use episodes per day was lower for IV users than heroin-cannabis smokers at both follow-up points (p = 0.013 and 0.0019). A higher proportion of IV users was HIV positive (p = 0.002). There were no significant differences in psychopathology, general health, criminality and social functioning between IV users and heroin-cannabis smokers at all three time points.
Heroin users who do not inject drugs but use other routes of administration may have increased risk for relapse to heroin use after inpatient rehabilitation and should therefore have equal access to harm reduction treatment services. Advocating a transition from injecting to smoking heroin in an African context may pose unique challenges.
Injecting and chasing heroin are the most common methods of heroin use described in the literature. Injecting heroin is reported to pose the most harmful effects due to risks of overdose, transmission of blood borne viruses, more severe symptoms of dependence, longer heroin-using careers and higher rates of criminality and homelessness . ‘Chasing the dragon’ is a method of heroin use whereby users inhale the vapour produced by heating heroin over a foil. Due to the severe harms associated with injecting, there have been harm reduction campaigns aimed at helping heroin injectors transition to inhaling heroin [2,3,4]. This could be a possible intervention in some African countries where there is a high prevalence of HIV and there are concerns about an increasing number of injecting heroin users. Within some contexts, however, the users’ accepted and familiar alternative to injecting heroin is smoking it in combination with cannabis.
South Africa, Kenya and Tanzania have reported a significant proportion of heroin users who smoke heroin combined with cannabis [5,6,7,8]. Data are however limited and the papers from Kenya and Tanzania are qualitative and therefore do not report on the specific numbers of heroin-cannabis smokers. In South Africa between 60 and 90% of heroin users entering treatment facilities report smoking heroin as their main method of heroin use . The common street names for heroin in South Africa are nyaope, whoonga and thai. Typically, a user rolls a joint of cannabis, pours over a bag of nyaope and smokes it . The reasons behind different routes of intake and drug combinations are not always fully understood. Unique cultural factors, pricing, availability of paraphernalia and the user’s subjective experience of the drug are said to play a role [6, 10, 11].
Different methods of drug use may however influence the severity of dependence and treatment outcomes. Furthermore, different methods of use may impact access to treatment. For example, in Kenya, access to opioid agonist maintenance treatment (OAMT) and other harm reduction services are reserved for injecting heroin users, and heroin-cannabis smokers have limited access . Similarly, in South Africa, of the few state- and non-government-funded OAMT clinics, the majority exclusively serve people who inject drugs . This is despite reports that roughly 23% or fewer may be injecting heroin users [12, 13].
In some African regions, much needed harm reduction services are slowly gaining impetus due to national HIV prevention and treatment campaigns for people who inject drugs. Whilst the roll-out of OAMT is much needed, it is also important to consider the larger heroin-using population and compare characteristics and treatment outcomes between heroin-cannabis smokers and heroin injectors. It is therefore worthwhile investigating different methods of heroin use and the biological, psychological and social sequelae thereof. These data may also help inform whether harm reduction campaigns that advocate a transition from injecting to smoking heroin would be advisable in areas where heroin is predominantly smoked with cannabis.
Participants were recruited from two state-funded drug and alcohol rehabilitation centres in the Gauteng Province of South Africa. The programmes entailed 1 week of inpatient detoxification followed by 6 to 8 weeks of psychosocial rehabilitation. Upon completion, most participants returned home and were encouraged to see their local social workers for follow-up and attend community-based self-help groups such as Narcotics Anonymous. The study was approved by the University of Witwatersrand Human Research Ethics Committee (M1704100).
A convenience sample of new admissions whose primary drug of use was heroin was screened for inclusion and exclusion criteria. In order to be enrolled in the study, participants were expected to
have been using heroin in the months prior to admission,
be older than 18 years of age,
be willing to provide locator information for follow-up to occur,
be able to provide informed consent.
Participants were assessed during rehabilitation and then followed up 3 months and 9 months after leaving inpatient rehabilitation. Participants were not compensated for their participation but were given 7 USD transport compensation if they returned to the research site for their follow-up interview. In some cases, the principal investigator (PI) did home and/or hangout-spot follow-up visits. Participants that were seen at home or hangout spots were not compensated. No telephonic interviews were done.
All baseline and follow-up interviews were conducted face-to-face by the PI who is a psychiatrist. Recruitment and data collection were conducted between July 2017 and February 2019. The PI was not part of the treating team at the rehabilitation facilities. Participants did not read or answer any of the questionnaires on their own. At baseline, a detailed socio-demographic and past substance use questionnaire created specifically for the study was administered. The Opioid Treatment Index (OTI) , which included sections on the past month drug use, past month injecting and sexual practices, social adjustment, past month criminal history and general health, was administered at baseline and both follow-up occasions. Drug use estimates in the OTI are based on the average use episodes of a substance per day. Drug use is expressed as a Q score which describes the frequency of drug use. A Q score of 1.00 to 1.99 indicates daily use and a score of greater than 2.00 indicates usage of more than once a day.
The Mini-International Neuropsychiatric Interview (MINI) version 7.0.2 for DSM-5  was administered at baseline and both follow-ups to determine the presence of the following psychiatric conditions: major depressive episode (MDE past and current), suicidality (current, life time and future risk), manic and hypomanic episodes, social anxiety disorder (SAD), obsessive compulsive disorder (OCD), post-traumatic stress disorder (PTSD), psychotic disorders, generalised anxiety disorder (GAD) and antisocial personality disorder (ASPD). Screening for ASPD was only done at baseline interview.
HIV status was determined by participants’ self-report from prior testing. Urine was collected for a Multi-Drug Urine Test (MDUT) for as many participants who were able to provide a sample. Urine collection was unsupervised; however, a research assistant was trained to identify any unusual changes in colour, temperature or smell. The MDUT tested for the presence of opioids, cocaine, amphetamines, methamphetamine, cannabis and benzodiazepines. Those who relapsed to heroin use after rehabilitation were classified as continued heroin users (CHU). CHU was determined by two factors: self-reported heroin use and/or positive for opioids on the MDUT. Therefore, in cases where no MDUT was available, self-reported substance alone was used to determine drug use.
Sample size estimation
Based on worst-case (for sample size) estimates of 50%, 5% precision and the 95% confidence level, a sample size of 385 would be required . A sample size of 300 for this project corresponds to a precision of 5.7% (rather than 5.0%), which was considered adequate. Sample size estimation for the comparison of intravenous (IV) user and heroin-cannabis smoker groups was based on the chi-squared test (for categorical variables) with up to 4 × 2 table size, and the independent samples t test (for continuous variables); for the detection of a medium effect size (w = 0.3 and d = 0.5 respectively) with 80% power at the 5% level of significance, minimum sample sizes of 122 and 128 respectively are required. Sample size calculations were carried out in G*Power .
Comparison of follow-up status (those seen and those lost to follow-up) for categorical variables was carried out by the χ 2 test. Fisher’s exact test was used for 2 × 2 tables or where the requirements for the χ 2 test could not be met. Continuous variables were assessed by the independent samples t test. Where the data did not meet the assumptions of these tests, a non-parametric alternative, the Wilcoxon rank sum test was used. Comparison of heroin-cannabis smokers and IV users was carried out analogously. Comparison of binary outcomes at enrolment, 3 months and 9 months, was performed by a generalised estimating equation (GEE) with the outcome as the dependent variable, observation point as the independent variable and participant as the repeated measure. Data analysis was carried out using SAS version 9.4 for Windows . The 5% significance level was used.
Description of sample at baseline
Over the recruitment period, 317 clients were screened. Eight did not fit the inclusion and exclusion criteria and five refused participation. A total of 304 participants signed consent and were enrolled in the study; however, four were withdrawn during baseline (BL) interviews as they were assessed as actively suicidal. The final sample thus consisted of 300 participants, 256 (85.3%) males. The median age at enrolment was 27 years (IQR 23–30 years, range 18–47 years), and 93.0% of the participants were Black/African South Africans (Table 1). Of the total, 200 (66.6%) were heroin-cannabis smokers, 89 (29.7%) were injectors and 11 (3.6%) used heroin only by chasing. Due to the small number in the chasing group and that 50% of all participants who reported chasing heroin also were heroin-cannabis smokers, they were grouped with smokers for further analyses. Fifty-nine participants (19.7%) reported smoking cannabis in the past month without heroin and of these, 37 were from the heroin-cannabis group, 22 injectors and 10 chasers. Heroin-cannabis smokers were significantly older at enrolment than IV users (27 years vs 25 years; p = 0.0062). The median age at first heroin use was significantly lower for IV users compared with heroin-cannabis smokers (18 vs 20 years, p = 0.0016). The median duration of heroin use was 7 years (IQR 4–9 year). Further details of the baseline sample have been presented in previous reports .
Baseline substance use
At baseline, 71.3% of the participants were using two or three substances and 21.3% were using four or more substances. The most common substances used, other than heroin and cannabis, were crack-cocaine, crystalmetamphetamine and methaqualone. At baseline, there was no significant difference in the median number of past month use episodes between IV users and heroin-cannabis smokers for heroin, crystalmetamphetamine, crack-cocaine and methaqualone.
Comparison between participants seen and lost to follow-up
Two hundred fifty-two participants (84.0%) were followed up at 3 months, and 225 (75.0%) were seen at 9 months after leaving inpatient rehabilitation. The chief reason for loss to follow-up at 3 and 9 months was unknown whereabouts of participants as families reported they were uncontactable and living on the streets (41% of participants lost to follow-up at 3 months and 46% at 9 months). Over the study period, 12 participants were not interviewed as they were incarcerated at the time of follow-up interview and four participants passed away. At 3 months, there was no significant association between those seen and those lost to follow-up in regard to demographic variables, substance history, psychopathology and HIV status. However, those followed up successfully had a higher proportion of participants living in formal housing at enrolment, compared with those lost to follow-up (p = 0.042). At 9 month follow-up, there were several significant differences between those seen and those lost to follow-up: those followed up successfully had a higher median duration of heroin use (7 vs 6 year; p = 0.033), lower proportion of those who used cannabis without heroin (p = 0.048), lower proportion of those with mental illness (p = 0.047), higher proportion of methaqualone users (p = 0.0098) and higher proportion of those living in formal housing (p Table 2 Treatment outcomes: comparison between heroin smokers and injectors
Criminality, social functioning and general health
At baseline, 83.7% had engaged in crime in the past month, 32.9% at 3 months and 39.6% at 9 months. There was a significant difference in the median crime score between heroin-cannabis smokers and IV users at baseline (p = 0.01) but not at the 3 and 9 month follow-up points. Social functioning scores reflect data on accommodation, relationships and employment. At all time points, there were no significant differences between the median social functioning scores of heroin-cannabis smokers and injectors or in their median general health scores (Table 2).
Injecting practices and HIV
There was a significant decrease in the proportion of IV users from 29.7% at baseline to 11.1% at 3 months (p Table 3 IV users and needle sharing
Of the initial sample of 300, 47.0% did not have an HIV test in the preceding 6 months. Of those who knew their HIV status, 18.5% were HIV positive. The prevalence of HIV was higher in IV users than heroin-cannabis smokers (p = 0.002).
This is the first study to compare characteristics and treatment outcomes between heroin-cannabis smokers and injecting heroin users. It was expected that IV users would fare more poorly in all domains of treatment outcome. Contrastingly, heroin injectors demonstrated higher abstinence rates, had fewer heroin use episodes and used fewer substances compared with heroin-cannabis smokers. Heroin-cannabis smokers also did not differ significantly to injectors in regard to psychopathology, general health, social functioning and criminality. Amongst injectors however, the overwhelming majority shared needles before and after treatment. There was also a higher prevalence of HIV and crystalmetamphetamine use than amongst heroin-cannabis smokers at both post-treatment follow-up points. In analysing these results, there are a few factors to consider, namely the impact of cannabis in the overall addiction severity, the role of smoked heroin and lastly contextual factors such as local treatment services and HIV prevalence.
Interestingly, although there is a paucity of data on heroin-cannabis smokers, there are numerous animal model studies examining the synergistic interactions of the cannabinoid and opioid systems. Animal model data describe the ability of cannabinoids to prime the endogenous opioid system and attenuate the effects of opioid withdrawal [20, 21]. In this way, cannabinoids are said to readily interact with the opioid system and thereby modify behavioural responses linked to reward and relapse related phenomena. Some suggest that this potentiates the pharmaceutical benefits of cannabinoids in opioid dependence and pain management [20, 22]. It may also however provide insight into why heroin-cannabis smoking is a preferred method of use in some regions. Cross-agonism within these systems could potentially provide a ‘better’ high whilst at the same time decrease the severity of withdrawal. Further studies of heroin-cannabis smokers may provide new insights in the field of cannabinoid-opioid biochemistry.
Clinical studies assessing the impact of cannabis use in heroin users in the United States (US) and Israel found that cannabis use in people receiving OAMT did not negatively impact heroin abstinence rates [23,24,25]. In the US, currently there are also debates around the role of cannabis in the opioid epidemic . It has been suggested that cannabis or cannabinoid products may be a less harmful alternative for those with opioid dependence and chronic pain [26, 27]. Those who refute this standpoint state that there is insufficient evidence to justify cannabis as an effective and safe analgesic and that cannabis acts as a companion drug that may increase use of opioids rather than abate it .
In our study, 50% of those who used cannabis only at first follow-up went back to heroin use 6 months later and 29% of those who abstained from cannabis continued heroin use later on. There was no significant difference in heroin abstention status at 9 months between those who used and did not use cannabis at the first follow-up. The data suggest that in this cohort cannabis use was not protective against heroin abstinence later on. Owing to the method of combination use, the risk for heroin relapse is expectedly higher in South Africa. There are however other challenges with relating international data to a South African cohort; from BL, a smaller proportion described using cannabis on its own (19.6%) and importantly our cohort received an abstinence-based approach and thus did not have the benefit of OAMT.
Methods of heroin use have evolved at varying time periods in different countries [29, 30]. The findings that heroin-cannabis smokers had higher rates of CHU and a greater number of daily heroin use episodes post-treatment is new. Furthermore, heroin-cannabis smokers and injectors did not differ in regard to the prevalence of psychopathology and total scores for social functioning and criminality. The similarities in these domains suggest that smoking heroin with cannabis resulted in equal levels of psychosocial distress. Cross-sectional studies in the UK describe more severe symptoms of heroin dependence in injecting users than chasers [31, 32]. A Spanish study found no major differences in the severity of heroin dependence between heroin injectors, smokers and sniffers in long-term users .
The median age at enrolment for IV users was lower and IV users began heroin use at a significantly younger age. This may reflect that IV users begin heroin use earlier however present sooner to rehabilitation presumably due to their concerns about the risks of injecting and sharing needles. Longer length of heroin use and higher frequency of heroin use episodes have been associated with poorer abstinence rates [34, 35]. In this study, heroin-cannabis smokers had a similar duration of heroin use and median number of heroin use episodes at baseline; therefore, it does not appear that these factors contributed to the lower abstinence rates. Additionally, some studies report poorer abstinence rates in younger patients; however, in this study, the older heroin-cannabis smoker group fared worse in regard to heroin use at 9 months [35, 36].
Research has suggested that IV use may result in higher peak serum concentrations of heroin but faster metabolism. Smoking heroin on the other hand results in direct alveolar transfer of heroin to cerebral arterial blood which could facilitate greater and more distinct central nervous system toxicity . The impact of heroin-cannabis smoking on the central nervous system and the dual effect of cannabis dependence may be possible reasons why the smokers in this cohort had lower rates of abstinence and used heroin more frequently. At both follow-up periods, the proportion of crystalmetamphetamine users was higher in injectors. There is some similarity to studies in the UK and US that found higher proportions of crack-cocaine or amphetamine users amongst IV users compared with heroin chasers [1, 37].
Amongst IV users, approximately 80% or more shared needles. Whilst this is in keeping with previous cross-sectional studies of IV users in South Africa [38, 39], it is concerning that in this prospective study, there was no positive change after rehabilitation. As expected, the prevalence of HIV was higher in IV users; however, unexpectedly, general health scores showed no significant difference between IV users and heroin-cannabis smokers at treatment entry and thereafter. There is growing concern about the risks for chronic obstructive pulmonary disease (COPD), asthma and pneumonia in cannabis smokers . In view of the fact that there is a high prevalence of heroin-cannabis smoking in South Africa, future studies should explore the prevalence of COPD in this population group. Psychiatric and non-psychiatric comorbidities in both heroin-cannabis smokers and injectors can be addressed by decreasing barriers to treatment, increasing access to treatment and implementing harm reduction-based interventions for heroin user in South Africa. The high rate of needle sharing, before and after detoxification, in a region with the highest HIV prevalence rate in the world reaffirms the shortcomings of abstinence-based treatment and an urgent need for needle exchange programmes and OAMT in South Africa. Additionally, continued heroin use amongst both injectors and heroin-cannabis smokers was high. Unlike many other prospective treatment outcome studies of patients receiving OAMT [34, 41, 42], heroin use in both injectors and heroin-cannabis smokers increased over time, suggesting that OAMT may improve outcomes in a South African heroin users seeking treatment.
This study whilst novel and robust in its results has some limitations. Firstly, we were only able to compare short-term results between heroin-cannabis smokers and injectors. It would be valuable to follow the cohort over a longer period to assess whether short-term trends are maintained. Secondly, the drug use section of the OTI takes into account the last three occasions of substance use in the past month. In this cohort, the majority of participants consumed heroin and cannabis daily at all three time points. Therefore, the Q score for heroin and cannabis is largely reflective of the average use episodes in the 3 days prior to interview. Day to day substance consumption may be affected by variables such as availability of money, availability of the substance and socialisation. Therefore, some may argue that assessing past three occasions limits the overall interpretation of the quantity and frequency of use. Lastly, this study did not specifically assess severity of dependence using a separate tool or scale. It rather looked at drug use, social functioning, injecting behaviour, criminality, general health and psychopathology as key treatment outcomes after inpatient rehabilitation. Whilst data is available regarding the frequency of heroin use, occasions of heroin use do not necessarily signify exposure when comparing different methods of use.
Compared to IV users, heroin-cannabis smokers had a higher proportion who had relapsed to heroin use 9 months post-rehabilitation. The findings therefore suggest that heroin-cannabis smokers should have equal access to OAMT and should be included in policy development towards harm reduction in heroin users. A harm reduction approach that supports injecting users’ transition to heroin smoking may increase the number of heroin-cannabis smokers in South Africa. Whilst this may decrease certain harms associated with injecting, it may unfortunately also pose further risks for more severe dependence on both cannabis and heroin.
Availability of data and materials
The datasets generated and/or analysed during the current study are not publicly available due participant anonymity but are available from the corresponding author on reasonable request.
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The authors would like to give their sincere thanks to the research assistant, Ms Rachel Monedi, for her dedication and support. The authors would also like to thank Dr Petra Gaylard (Data Management and Statistical Analysis (DMSA)) for assistance with the statistical analyses.
This study was supported by the M and J Miller Foundation and a South African National Research Foundation grant.
Nirvana Morgan is a recipient of a Cassandra Miller-Butterworth Fellowship for a clinician-scientist PhD. This fellowship, from the M and J Miller foundation, allowed Nirvana Morgan to conduct this study as a full-time PhD student and contributed to the running costs of the study.
Dr Morgan is also a recipient of a South African National Research Foundation grant (TTK 170430229217) which further supported this study.
These funding sources had no role in the design of the study, data collection, data analysis, the writing of the manuscript, or the decision to submit this paper for publication.
Department of Psychiatry, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg, 2193, South Africa
School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Department of Psychiatry, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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In several countries, especially in Africa, the dominant method of heroin intake is smoking a joint of cannabis laced with heroin. There is no data exploring the impact of smoking heroin with cannabis on treatment outcomes. To compare treatment outcomes between people who inject heroin and people who smoke heroin with cannabis. Three hundred heroin users were assessed on admission to inpatient rehabilitation and after treatment. We compared drug use, psychopathology, criminality, social functioning and general health between heroin injectors and heroin-cannabis smokers at treatment entry, and at 3 and 9 months after rehabilitation. The sample comprised 211 (70.3%) heroin-cannabis smokers and 89 (29.7%) heroin injectors. Eighty-four percent were followed up at 3 months and 75% at 9 months. At 9 months, heroin-cannabis smokers had a higher proportion of those who relapsed to heroin use compared with intravenous (IV) users (p = 0.036). The median number of heroin use episodes per day was lower for IV users than heroin-cannabis smokers at both follow-up points (p = 0.013 and 0.0019). A higher proportion of IV users was HIV positive (p = 0.002). There were no significant differences in psychopathology, general health, criminality and social functioning between IV users and heroin-cannabis smokers at all three time points. Heroin users who do not inject drugs but use other routes of administration may have increased risk for relapse to heroin use after inpatient rehabilitation and should therefore have equal access to harm reduction treatment services. Advocating a transition from injecting to smoking heroin in an African context may pose unique challenges.
Injecting marijuanas effects
A new study found that injecting pure THC triggered schizophrenia-like behaviors in subjects. But, uh, does anyone actually consume weed this way?
The study, conducted by schizophrenia researchers at the Veterans Affairs Healthcare System in Connecticut, and recently published in Neuropsychopharmacology, involved shooting up 22 healthy individuals with 2.5mg THC, 5mg THC, or a placebo (0mg THC). The subjects had previously been “exposed” to cannabis, but none had been diagnosed with cannabis use disorder.
After three separate days of mainlining pure THC, the subjects reported experiencing schizophrenia-like symptoms, increased anxiety, altered perceptions, euphoria, and a host of memory and speech issues. Their blood also showed increased levels of cortisol, the primary stress hormone. Not surprisingly, the researchers concluded that THC produces psychotic behaviors, and more studies are needed to see how cannabinoid receptors may contribute to psychotic disorders.
Usually when we see anything about injecting THC or “marijuanas,” it comes from satirical social media accounts that claim shooting up weed can cause everything from suddenly turning someone gay to spontaneous death (again, these are memes). But intravenous administration of THC is a standard (though not terribly common) practice in cannabis studies, since it gives researchers precise control over dosing. The only problem with this study and others like it is that no one actually injects pure THC. There’s a reason why most consumers prefer to smoke or vape cannabis, after all.
When someone smokes, let’s say, a one-gram joint rolled with weed containing 25 percent THC, that joint contains, roughly, 250mg of THCA, the form of THC that doesn’t get anyone high. Heat converts some THCA into THC — the stuff that gets people lit — but only some THCA turns into the psychoactive form. The average time that heat is applied to the joint isn’t long enough to convert all of the THCA to THC. Furthermore, a bunch of converted THC gets lost in the smoke that wafts from the joint, and even more THC gets stuck in the ash.
So, by the end of it, even if just one person smoked that entire 1-gram joint to the face, they’re only getting a small fraction of that potential 250mg THC, not to mention a cornucopia of other compounds such as other cannabinoids, terpenes, flavonoids, and polyphenols — which all may interact with our brain’s cannabinoid receptors, dulling the negative effects of THC.
In other words, shooting someone up with 2.5mg or 5mg pure THC is kind of a lot, especially for non-stoners, which this study focused on.
In addition to there being next-to-no people who shoot up THC distillate or diamonds on a regular basis, no one shoots up actual weed, either. Back in the ‘70s and ‘80s, some idiots tried that, and they developed what’s called “intravenously injected marijuana disorder.” Basically, folks would boil weed buds into a “broth,” pull that filtered broth up into a syringe, then inject it. Rather than getting lit, they got sick AF instead, which included bouts of vomiting, intense muscle pains, and serious heart problems.
Here’s the thing about IV marijuana disorder, too: There are practically no new case studies on it after 1986, suggesting that only a handful of people did it back in the day. Why? Obviously, it sucks, and it’s potentially life-threatening. Which is why, today and in the past, folks have stuck to puffing their pot.
Does this mean that everything about the VA study is bogus? Not entirely. We know that the endocannabinoid system plays a role in some mental disorders, and cannabis use can aggravate some psychotic symptoms in people particularly prone to them. However, many cannabis patients consume weed to alleviate symptoms of their personality or mood disorders, too, so the issue isn’t black-and-white, nor is it clear-cut.
Oh, and in case if you’re wondering if you can snort weed, yeah, technically, that’s possible. But you’ll end up blowing pot-snot all day and never catching a buzz.
Can you "inject marijuanas," as the satirical memes suggest? Yes, but it’s a really, really stupid thing to do, according to a new study.