CBD is broken down by the same enzyme as 75% of medications and drugs. Here is a list of the medications that interact with CBD and if it's safe to mix. CBD is being used by millions worldwide, yet most still ask the same question. Can you combine different CBD products? Find out now.
CBD Drug Interaction List: Is it Safe to take CBD with your Medications?
CBD is phenomenally popular right now. It’s being used to treat pain, anxiety, epilepsy, psychosis, and even neurodegenerative diseases like Alzheimer’s and Parkinson’s. It’s been called a “wonder drug,” without irony, and it has essentially no known downsides. It is readily available and easy to take.
At the same time, it’s important to be aware that CBD can interact with some medications. Taking it at the same time as other drugs can affect CBD’s dosage and effects, and can even change how your body breaks it down.
This article is your guide to safely taking CBD alongside your other medications and supplements. First, it has a quick overview of how CBD interacts with other drugs in your body, and then it lists the most common drugs that interact with CBD, and which you should be careful about taking at the same time. If you want to skip ahead, you can find the list here.
The CYP450 Pathway
Once a drug enters your system, its molecules are circulated through your blood and interact with your cells and tissues, doing whatever it is they’re supposed to do. Painkillers reduce pain signals and can stop swelling, antidepressants interact with brain cells to change your brain chemistry, and so on.
Once they’ve done their work, your body needs to get rid of the drug molecules. Too much of any drug in your bloodstream is toxic, and can start to harm your body.
Your body uses all kinds of systems to get rid of drugs, and the most important of these are enzymes–chemicals that break down other chemicals. The largest set of enzymes are the cytochrome p-450 group (or CYP450), which are responsible for breaking down about 75% of the medications and recreational drugs that we take.
CBD and the CYP450 Pathway
CBD interacts with the CYP450 system in three ways. First, some of the enzymes in the system are responsible for breaking down CBD molecules, as they are for molecules of other drugs. That’s normal–nothing to worry about there.
Second, CBD can affect how CYP450 enzymes are produced by your liver, making it produce not enough of some enzymes or too much of others. This can stop your liver from processing some drugs, like the epilepsy medications clobazam and valproic acid.
Third, and most importantly, CBD can actually stop many of the CYP system’s enzymes from working properly. This is called “inhibition,” and it can cause problems if it prevents the enzymes from breaking down other drugs. Sometimes, the enzymes are responsible for activating other drugs instead, but the same problem comes up–if CBD stops the enzyme from working, then it doesn’t do its normal job, and the other drug won’t behave normally, which can have negative consequences.
For instance, there’s a group of antidepressants called selective-serotonin reuptake inhibitors, which include drugs like citalopram, norfluoxetine, and sertraline. Normally, an enzyme called CYP3A4 breaks down molecules of those drugs, making sure they don’t build up to unsafe levels that can damage cells or tissues. CBD inhibits CYP3A4, though, which means that taking CBD and sertraline at the same time could be dangerous. CYP3A4 wouldn’t break the sertraline down, and it would accumulate for far too long.
It’s worth noting that CBD isn’t the only thing that does this. The herbs St. John’s Wort and goldenseal can also stop CYP450 enzymes from working properly, as can grapefruit and starfruit juice, and even tobacco.
Drugs that Interact with CBD List
That brings us to our list. Remember, the general rule is that you need to be careful taking CBD at the same time as any drug or medication that gets processed by CYP450 enzymes. If you’re thinking about doing so, be sure to check with your doctor first.
Here are the most common of those drugs and medications. They include many painkillers, anti-inflammatories, antipsychotics, antidepressants, anticonvulsants, statins, opioids, and other groups.
Can You Combine Different CBD Products?
Experimenting with and discovering new products is part of the joy of CBD. The vast selection on offer today not only allows you to find a product that’s ideal for your lifestyle, but it can be a fun experience too.
Research shows that CBD is safe and non-addictive. As a result, it stands to reason that you could take multiple CBD products and still be safe. Today, we investigate whether this is actually true. Read on to find out whether you can really combine different CBD products.
Are There Any Risks To Combining CBD?
While some people may experience lethargy and a dry mouth, there seems to be little to worry about when it comes to consuming multiple types of CBD products together.
A study published in 2011 in Current Drug Safety, suggests you would need to consume almost 20,000 mg of CBD in a short space of time for CBD to become toxic. This would not only be next to impossible, but it would also be very expensive.
In addition, CBD has been ruled as safe and non-toxic. The World Health Organisation (WHO) published a report in 2018, confirming that this is the case.
What this suggests is that, in general, normal doses of CBD are safe – even when multiple different types of products are consumed together. However, if you have never consumed CBD before, you should take a low dose to start with, and only increase the amount if you don’t experience adverse effects.
Tips (and Benefits) of Combining CBD Products
Combining different CBD products can be beneficial. It allows you to keep up your CBD levels throughout the day, while also allowing you to enjoy several different product types and flavor combinations. Below, we give you our top three tips for combining different CBD products, while also staying safe.
1. Get to Grips with Micro-dosing
Micro-dosing involves using a very small amount of CBD. Typically, consumers split up their regular dose throughout the day. For example, if 50mg a day works for you, it’s possible to take three ~15-20mg doses at different points in the day. Microdosing in this way means you have more opportunities to try different products and find a combination that works for you.
Once you have figured out an appropriate routine, you can start safely experimenting and combining different CBD products. Bear in mind however that many users describe CBD oil’s effects as subtle – do not expect any instantaneous miracles or profound epiphanies.
2. Vary Your Consumption Methods
The whole point of combining different CBD products is to experience the pleasure of trying something new. You could just microdose using the same product three times a day, but then you would lose out on some of the fun.
Try mixing up your consumption methods and experimenting with new things. The CBD market is huge, and it would be a waste not to play around and try out the many different products on offer. You might even find a new favorite product.
Something to note here is that different consumption methods work in different ways. Vaping CBD will take effect quickly, sublingual oils will be a bit slower, and capsules or edibles may take even longer to kick in. You can’t expect all the products you try to work in the same way, and so don’t be surprised when that CBD gummy bear you just ate doesn’t show any effects for an hour or two.
3. Try a Totally NEW Product Like Our CBD PurePicks!
At PureKana, we work tirelessly to develop our product range and to deliver new, exciting options for loyal customers. One of our newest additions is CBD PurePicks; basically toothpicks that are infused with CBD on both ends for active use.
PurePicks are unique in terms of CBD delivery, but they are highly effective due to the way the CBD is absorbed through vessels in the mouth. They are also ideal for combining with other CBD products since they are simple to consume, and can be taken on the go. They also offer a relatively small amount of CBD, and come in packs of 10 picks in several delicious flavors.
Final Thoughts on Combining CBD Products
All things considered, combining different CBD products is a completely safe thing to do, as long as you pay attention to your body. If you are taking medication, have a medical condition, or are pregnant, always discuss CBD with a medical professional before taking it.
If you are taking CBD to support your general health, you may wish to take a few different doses throughout the day. By following our above tips and paying attention to what your body is telling you, you can stay fully safe when combining different CBD products.
Got any tips for combining CBD products? What are your favorite products to try out when mixing and matching? Let us know down in the comments!