What many people don’t know is that dog CBD oil can interact with other medications by either enhancing the effect, or by interfering with the metabolism of some. It can be so difficult to watch our dogs age and succumb to the aches of elderly life. On top of that, you may not always know when your dog is suffering, because they're so good at keeping the discomfort hidden. Typically, when they do become noticeably uncomfortable, it's often because the pain is quite severe. Becau
Can my Dog take CBD Oil While Taking Other Medications?
With the pet CBD market industry exploding globally, it’s no surprise that we need to look out for any drug interactions. What many people don’t know is that dog CBD oil can interact with other medications by either enhancing the effect, or by interfering with the metabolism of some.
In this blog, we’ll discuss why it’s important to consult with your veterinarian first before using CBD pet products.
Not only is this important so that you can get a proper diagnosis for a medical condition, but your veterinarian will be able to discuss any possible side effects if CBD is used together with other pet meds.
Here’s what you need to know to fully protect your pet, and to make sure that there are no drug interactions.
CBD can alter the way your dog processes certain medications
Yes, although cannabidiol (CBD) is a natural supplement that is beneficial for numerous health conditions in pets, as well as for chronic pain, insomnia, depression , and anxiety, CBD does have the potential to interact with certain medications.
CBD is derived from the hemp plant, yet it can also come from the marijuana plant. CBD hardly ever contains delta-9-tetrahydrocannabinol (THC), which is the compound that gives marijuana its “high” effect. High-quality CBD is non-toxic and considered safe for pets and humans alike.
There are almost no side-effects, apart from those coming from a low-quality CBD oil that may contain contaminants. It’s always best to look out for the compromised quality of some CBD oils.
You’ll need to discuss with your veterinarian all supplements, over-the-counter meds and prescription meds that your pet may be taking. Today research continues to demonstrate how effective CBD oil is for pets, yet one still needs to examine how it can interfere with the metabolism of pet meds and other supplements.
Benefits of CBD Oil for Dogs
Cannabidiol (CBD) extract is quickly gaining popularity as a natural alternative for managing pain, inflammation, and a variety of medical conditions, including epilepsy. However, recent reports have called into question the safety of CBD when used together with other pet meds. It’s also good to note that using a compromised quality or low-quality CBD oil raises the risk of side effects.
A recent 2019 study by the University of Korea, demonstrates that the CBD anti-cancer protein shows potential in killing tumor cells. The researchers tested the synergistic effect of CBD with a cancer destroying protein called TRAIL. (TNF related apoptosis- inducing ligand.)
The study concluded that TRAIL and CBD created apoptosis separately in colorectal cancer cells. The researchers also found that together, both reduced cancer cells a lot. “ To the best of our knowledge,” they wrote, “this is the first report that cannabidiol induces significant TRAIL-induced apoptosis of colorectal cancer cells,” noting that earlier reports suggested that a different protein response was responsible for cancer-cell death.” via MDPI Journals.
FDA & CBD
The FDA has also tested the chemical content of cannabinoid compounds in some of the products, and many were found to not contain the levels of CBD they claimed to have. We have also heard reports of CBD potentially containing contaminants (e.g., pesticides, heavy metals); we are looking into this.
Some cannabis products are also being marketed as pet food and health products for animals. The FDA has not approved cannabis for any use in animals and recommends pet owners talk with their veterinarians about appropriate treatment options for their pets.” via FDA, 2019.
Blood Pressure and CBD Oil
High doses of CBD oil may potentially drop blood pressure resulting in lightheadedness and possibly dizziness in people. It’s always best to consult with your veterinarian for the best advice prior to purchasing a CBD product. That said, the positive side of CBD oil use is that it may be good for patients with high blood pressure. CBD together with regular exercise and a healthy diet help to regulate hypertension.
A 2017 study by Dr. K Jadoon on CBD and its effects on blood pressure demonstrated the following:
The study concludes that “acute administration of CBD reduces resting BP and the BP increases stress in humans, associated with increased HR. These hemodynamic changes should be considered for people taking CBD. Further research is required to establish whether CBD has a role in the treatment of cardiovascular disorders.”
CBD Oil Interacts with Anti-Seizure Meds
A study researching CBD interactions with seizure meds in people added that “ Because all of the participants are also taking other seizure drugs while they are receiving the investigational therapy, investigators checked the blood levels of their other seizure drugs to see if they changed. “With any new potential seizure medication, it is important to know if drug interactions exist and if there are labs that should be monitored while taking a specific medication,” said lead author Tyler Gaston, MD,” via Science Daily.
Dr. Gaston and her colleagues found that there were significant changes in levels of the drugs clobazam (and its active metabolite N-desmethylclobazam), topiramate, and rufinamide in both adults and children, and zonisamide and eslicarbazepine in adults only.
Except for clobazam/desmethylclobazam, however, the drug levels did not change outside of the normally accepted range. In addition, adult participants in the study taking clobazam reported sedation more frequently.
Additionally, when seizure patients were using valproate, they added that “Tests also showed that participants taking valproate and CBD had higher ALT and AST (liver function tests) compared with participants not taking valproate.
Very high ALT and AST indicate abnormal liver function, but significant ALT and AST elevation occurred only in a small number of participants (4 children and 1 adult), and the levels returned to normal after discontinuation of valproate and CBD.”
The study concludes that “The findings emphasize the importance of monitoring blood levels of antiepileptic drugs as well as liver function during treatment with CBD. “
A perception exists that since CBD is plant based, that it is natural and safe; and while this may be mostly true, our study shows that CBD, just like other antiepileptic drugs, has interactions with other seizure drugs that patients and providers need to be aware of,” said Dr. Gaston.”
CBD as a natural supplement does not cause a “high” in pets, but may cause a reaction when used together with anti-seizure meds. Cannabinoids have been shown to inhibit cytochrome P450 enzymes by using up these enzymes, and by inhibiting how other enzymes work.
When cannabidiol oil is consumed by dogs in large amounts, a large group of enzymes may be altered in the same way that grapefruit alters enzymes.
Most pet meds are metabolized in the liver via certain enzymes that are made in it. CBD works in the same way that grapefruit does, and may use up all the enzymes and also alter the effectiveness of pet meds.
NSAIDs and Corticosteroids
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are a class of drugs commonly used to control pain and inflammation in dogs. NSAIDs help many dogs lead a life that is more comfortable for them, but what about interactions with CBD oil? CBD oil has the potential to make pet meds less effective.
That said, pet parents should take every precaution to ensure that there are no interactions with any of their pet meds or supplements, and even NSAID’s, corticosteroids, pet herbal supplements and vitamins. The potential for adverse reactions will also depend on the body chemistry of your pet and the dose of the prescription or supplement.
Administer CBD oil 2 hours before or 2 hours after giving pet meds or supplements.
NSAID’S include the following:
Meds like Gabapentin when taken together with CBD can cause lethargy in pets. It’s important to discuss CBD use with your veterinarian prior to administering.
Common corticosteroids include the following:
The most common symptoms when using these are gastrointestinal issues like lack of appetite, vomiting, diarrhea, and even ulcers. We all know that pets cannot take both NSAID’s and corticosteroids at the same time, but what about cannabidiol oil and NSAID’s and corticosteroids?
CBD oil can also enhance the effectiveness of certain drugs and one may be able to lower the dose of pet meds or therapy when using CBD oil. Pet meds that are used for pain relief need to be administered carefully when using them together with CBD oil.
Galliprant For Dogs
It can be so difficult to watch our dogs age and succumb to the aches of elderly life. On top of that, you may not always know when your dog is suffering, because they’re so good at keeping the discomfort hidden.
Typically, when they do become noticeably uncomfortable, it’s often because the pain is quite severe. Because of that, it’s so important to keep a close eye on your dog and try to notice discomfort before it becomes too serious of a problem.
When you notice changes in your dog, it’s wise to get them to a vet. However, keep in mind that the medicines your doctor may prescribe aren’t always going to be the miracles they may seem to be.
Consequently, it’s important that you have plenty of knowledge about the medications your vet might recommend. To arm you with all the information you’ll need, we’re taking a look at the uses, benefits, side effects and dosages for Galliprant, as well as some alternatives you can consider.
What Is Galliprant For Dogs?
If you’re familiar with ibuprofen and aspririn, then you’ll know essentially what an NSAID is. Galliprant is an NSAID designed for animal use, which can help with inflammation as well as the pain that can result from it. While it is similar to medications that humans can get over the counter, it’s important that Galliprant only be used under the orders of a vet. Otherwise, things can get pretty dicey for your pet.
How Galliprant Works
Many NSAIDs interfere with the COX enzyme in order to help with relieving pain from a variety of different kinds of inflammation. That said, some NSAIDs can be specifically designed to work for specific kinds of inflammation, mainly acute and chronic inflammation, which can reduce the negative effects that can occur when compared to those that target any inflammation.
Galliprant is a non-COX drug and works differently than NSAIDs. Galliprant is one of the options that targets more specific kinds of pain. Specifically, it’s a great options for osteoarthritis in canines because it keeps a handle on the EP4 receptor. As a result, if this specificity, it’s one of the few options that can be easier on dogs who have a hard time with NSAIDs.
On top of that, other options can require keeping an eye on vital organs, which can get invasive as well as costly. However, Galliprant typically doesn’t have this requirement, making it a little safer than others.
Unlike other NSAID medications, which can be used for a variety of pain types, Galliprant is typically used for osteoarthritis. This is an issue that can cause problems for one out of every five dogs as they get older. Furthermore, it’s one of the common types of arthritis out there.
Galliprant For Canine Osteoarthritis
As your dog ages, osteoarthritis gains traction as years of movement result in cartilage in your dog’s joints breaking down. As that cartilage degenerates, it can result in more pain for your dog because their bones begin to grind together rather than being cushioned during movement.
Depending on the specific dog, osteoarthritis may not show up until the dog is older. However, in some cases it can begin to show up before the dog has even reached one year of age. It’s these cases in which Galliprant can be a useful tool. It’s worth knowing that dogs as young as nine months can use the medication safely.
This is important to note because many other options out there can be unhealthy for dogs with immune systems that are still in development. Do keep in mind that if Galliprant for dogs is being used for a longer period of time, it will be necessary to keep an eye on how it’s working in the body.
For the most part, you’ll be able to tell that your dog is having problems with arthritis because they’ll be less willing to get up, go for walks, or engage in other activities that they enjoyed in the past.
Though many think otherwise, arthritis can show up at any time, so it’s going to be important to watch out for the symptoms. The earlier you can catch them, the better off your dog will be.
In addition to that, you may also notice some of these other signs:
- Trouble standing
- Moving more slowly and carefully
- Sleeping a great deal more
- Lowered mobility
- Swollen joints
- Depression, irritability or other personality changes
- Weight gain
- Trouble laying down
- Odd movements, like limping
- Obvious joint deformities
- Aggression involving sensitive areas
- Lameness that can be intermittent
- Joint pain and inflammation
It’s worth remembering that while these are signs of arthritis, they can also be signs of other issues. Only your vet will be able to diagnose your furry friend and make sure they get the correct treatment. Your vet will evaluate your pet’s clinical signs, take their body weight, and take baseline blood tests to recommend a steroidal anti inflammatory drug, other NSAIDs, and concurrent therapies to help manage how your dog experiences pain.
Understanding Dog NSAIDs
There are a wide variety of NSAIDs on the market, including options like Galliprant, Metacam, Previcox, Rimadyl, and Deramaxx. Some of these options can be safer for your pet than others. For example, choosing to administer Galliprant tablets to manage pain and inflammation is an option that can be used when you want to avoid a lot of side effects, but keep in mind that NSAID effects will still exist.
NSAID side effects can be quite troubling for pet owners, so it’s a good idea to have a full understanding of them before you provide the medication to your pet. Keep in mind that you do have some other options to avoid the most common adverse reactions.
Dosages For Galliprant
Just like with any medication, it’s important that you follow your vet’s instructions when giving your pet Galliprant. This includes not giving anti inflammatory drugs on an empty stomach, even if your pet experienced a decreased appetite and doesn’t want to eat. It makes sense that you want to do everything you can to keep your pet from being in pain, but giving them a higher dose without your vet’s instruction can result in extremely negative effects.
Your vet knows the exact dosage your pet needs for effective results while trying to avoid as many side effects as possible. Causing your dog to overdose on Galliprant can create some terrible, lasting results on your pet.
Overdoses by pets on NSAID medications can be more common than you might expect. Even when their owners are following the correct dosage, pets can end up getting into the medication and consuming too much.
Some of the chewable tablets can be flavored in ways that are delicious to dogs, resulting in them going to town on the entire container. Unfortunately, issues like this can result in extreme amounts of liver damage and even death.
Precautions With Galliprant For Dogs
There are a few things to keep in mind if you think Galliprant might be a good option for your dog. Firstly, your vet needs to know about any conditions or other medications your dog might be on. In addition, any allergies they may have to such medications. That way, you can limit adverse reactions that your pet might have.
It’s not a good idea to administer Galliprant for dogs alongside corticosteroids or other NSAID medications. If your dog tends to have issues with grapiprant, they should not take Galliprant. For those who have small dogs, those that are under 8lbs can have difficulty getting the correct dose.
Keep in mind that taking Galliprant as a medication is rather new, so not all of the potential effects of it are known.
Side Effects Of Galliprant For Dogs
Nonsteroidal anti inflammatory drugs can make a difference for canine osteoarthritis pain. As an effective medication for the inflammatory pathway, a nonsteroidal anti inflammatory drug could be prescribed to help your pet. However, just like any medication, and particularly NSAIDs, there are side effects to look out for.
Keep an eye out for the following common adverse reactions of non steroidal anti inflammatory drugs:
- decreased appetite
Issues involving the gastrointestinal system can be very common with these kinds of anti-inflammatory, non-steroid medications.
That said, many find that dogs receiving Galliprant doesn’t seem to have effects that are as intense as other NSAID options for their dog.
Pregnant or lactating dogs, dogs younger than 6 months, dogs older than 7 years old, and overweight dogs have special considerations worth discussing with your vet.
In accordance with veterinary medicine best practices, your vet may prescribe other anti inflammatory drugs for lactating dogs and dogs younger than 6 months old.
Alternative Medications For Dog Pain
Because of adverse reactions as well as unpleasant side effects that can occur, pet owners often prefer to look for alternatives that might be a bit more gentle on their canine companion. This is especially true with medications like Galliprant for dogs, where it’s still just too new to understand every effect it might have on your dog’s body. The good news is, there are some natural alternatives out there!
CBD For Dogs
There isn’t yet a magical medication that keeps your dog young and happy forever, but there are supplements that can help them quite a bit! Among these is CBD, which can provide a lot of benefits for your dog in a very natural way.
There has been a lot of research done on CBD in general over the past 30 years or so. That said, it’s only in more recent times that we’ve started discovering the real help provided by CBD for pets. When it comes to assisting your pets, whether you’re trying to keep them healthy or alleviate arthritis symptoms, it’s absolutely worth trying out.
CBD is being investigated all over the world for many uses. However at this time, as the manufacturer of CBD products, we are not allowed to discuss that subject publicly nor we are not allowed to imply that CBD can be used for any specific treatment.
CBD For Managing Pain
When it comes to dealing with the pain of dog arthritis, CBD can be very useful. In learning how, it can help to know where that pain comes from. Osteoarthritis, like many types of pain, comes from inflammation within the body. While we don’t always see the inflammation, we can feel the effects.
CBD works like a natural substance that is capable of fighting this inflammation. As a result, it’s also able to relieve the pain your dog is feeling. By affecting the inflammation in a natural way, it’s able to protect your dog without all those added side effects.
CBD As A Joint Support Product
CBD can also be a fantastic option for assisting your pets with the health of their joints overall. As a result, they won’t need to worry as much about pain and can maintain their youth for longer. In addition, you also get a lot of options for how to give your pet CBD. Innovet, for example, offers both tasty CBD treats and CBD oils that can assist the overall health of your dog, as well as ensuring their joints are feeling great! Innovet also offers its new product, Advanced Mobility Support for Hip and Joints, specially formulated for arthritic and senior dogs.
Another useful substance you should consider when it comes to the health of your dog’s joints. There are a number of supplements out there for your dog that include this ingredient, which is able to assist in promoting synovial fluid and cartilage that make sure your dog can move around easily.
Overall, glucosamine is something that occurs in the body naturally, but adding more of it can be very useful in encouraging and protecting your dog’s joints. So if you’re concerned about the health of your dog’s joints, adding this as a supplement is a great idea.
Consider Feeding Your Dog Raw Food
Another useful tool that not everyone considers is changing up your dog’s diet. In the wild, dogs and their canine family members would typically eat raw meat from the animals they hunt. Consequently, many believe that a raw meat diet can be the best possible option in keeping your dog healthy.
If you’re interested in a raw food diet for your dog, then it’s a good idea to check in with your vet. They can give you a solid rundown of how, what and when to feed your dog so that they get the best possible results from the diet.
Galliprant For Dogs: The Bottom Line
Keep in mind that while osteoarthritis can be uncomfortable for your dog, it’s absolutely not something that is going to destroy your dog’s life. There are many options out there you can take to help them feel well and be able to get around more easily.
While you’re checking out your options, it can help to get a good feel for all of them. Consider the benefits, side effects and potential adverse reactions. It can also be helpful to visit a holistic vet using CBD to get a complete picture.
The more knowledge you have, the easier it will be to make the best possible choice for the health of your canine buddy.
Dr. Ivana Vukasinovic
Doctor of Veterinary Medicine, University of Belgrade
Ivana Vukasinovic grew up in Serbia and attended the University of Belgrade where she received a degree in Veterinary medicine in 2012 and later completed surgical residency working mostly with livestock. Her first year of practice was split between busy small animal practice and emergency clinic, and after two more years of treating many different species of animals, she opened her own veterinary pharmacy where an interest in canine and feline nutrition emerged with an accent on fighting animal obesity. In her free time, she acts as a foster parent for stray animals before their adoption, likes to read SF books and making salted caramel cookies.
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